It has numerous biotechnological applications, there is no risk of transmission of infectious diseases and for being genuinely Brazilian is cheaper their production. In 2015 this bioproduct was patented and licensed by ANVISA (National Health Surveillance Agency) and CONEP (National Council of Ethics in Research) for use in clinical research in a trial phase I / II. Based on that researchers from Cevap - Center for the Study of Venoms and Venomous Animals of UNESP - proposed about 20 years ago the prospect of a new heterologous sealant from a Spase isolated from Crotalus durissus terrificus snake venom and fibrinogen purified from large animals (buffaloes). It can polymerize acquiring seala nt and adhesive capacities by forming a stable network. Snake venom serine proteases (SPases) have type-thrombin enzymatic activity (thrombin like-enzyme) acting on the hemostatic system converting fibrinogen to fibrin.
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